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Patents

 

  • Flint, D.H.; Silverman, R.B. U.S. Pat. 4,528,028 (July 9, 1985) “Use of Certain Halogen-Containing Amino-Acid Compounds for Controlling the Growth of Unwanted Plants.”
  • Estreicher, H.; Flint, D.H.; Silverman, R.B. U.S. Pat. 4,582,529 (April 15, 1986) “Use of Certain Acetylene-Substituted Amino-Acid Compounds for Controlling the Growth of Unwanted Plants.”
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 5,563,175 (October 8, 1996) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 5,599,973 (February 4, 1997) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 5,608,090 (March 4, 1997) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. Australian Pat. 677008 (April 10, 1997) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. New Zealand Pat. 253459 (July 9, 1997) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 5,684,189 (November 4, 1997) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 5,710,304 (January 20, 1998) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. Russian Pat. 2,103,259 (January 27, 1998) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 5,847,151 (December 8, 1998) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. Russian Pat. 2140901 (Nov. 10, 1999) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. Czech Republic Pat. 286106 (Jan. 12, 2000) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 6,028,214 (February 22, 2000) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 6,117,906 (September 12, 2000) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. U.S. Patent 6,140,366 (Oct. 31, 2000) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R. U. S. Pat. 6,197,819 (March 6, 2001) “Gamma Amino Butyric Acid Analogs and Optical Isomers.”
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 6,255,345 B1 (July 3, 2001) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R.B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 6,262,120 B1 (July 17, 2001) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Huang, H.; Zhang, H. Q. U.S. Pat. 6,274,557 B1 (Aug. 14, 2001) “Inhibition of Nitric Oxide Synthase by Amino Acids and Dipeptides”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. U.S. Pat. 6,291,526 B1 (Sept. 18, 2001) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. Danish Pat. DK/EP 0641330 (Dec. 3, 2001) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. Singapore Pat. 9608718-4 (Jan. 4, 2002) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. U.S. Pat. 6,342,529 B1 (Jan. 29, 2002) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 6,359,169 B1 (Mar. 19, 2002) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. Austrian Pat. AT E 207052 T1 (Mar. 25, 2002) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. Hong Kong Pat. HK1011022 (Mar. 28, 2002) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. German Pat. 69330949 T2 (Apr. 4, 2002) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. Greek Pat. 3037855 (Apr. 29, 2002) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 6,414,024 B1 (July 2, 2002) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Lee Y. U.S. Pat. 6,416,861 (July 9, 2002) “Organosilicon Compounds and Uses Thereof.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A. U.S. Pat. 6,525,096 B1 (Feb. 25, 2003) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. Slovakian Patent 283,281 (March 3, 2003) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Yuen, P.-W.; Sobieray, D. M.; Franklin, L. C.; Schwindt, M. A.; Silverman, R. B.; Andruszkiewicz, R. Mexican Patent 215885 (August 18, 2003) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Pan, Y. U. S. Patent 6,794,413 (September 21, 2004) “Compounds and Related Methods for Inhibition of γ-Aminobutyric Acid Aminotransferase.”
  • Silverman, R. B.; Hah, J.-M.; Gómez Vidal, J. A. U. S. Patent 6,803,486 (Oct. 12, 2004) “Selective Neuronal Nitric Oxide Synthase Inhibitors.”
  • Silverman, R. B.; Yuen, P.-W.; Franklin, L. C.; Andruszkiewicz, R.; Sobieray, D. M.; Schwindt, M. A. Canadian Pat. 2,134,674 (Dec. 21, 2004) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Pan, Y. U. S. Patent 7,381,748 (June 3, 2008). “Compounds and Related Methods for Inhibition of Gamma-Aminobutyric Acid Aminotransferase.”
  • Silverman, R. B.; Ji, H. U.S. Patent 7,470,790 (Dec. 30, 2008). “Heteroaromatic Selective Inhibitors of Neuronal Nitric Oxide Synthase”
  • Silverman, R. B.; Hah, J. M.; Gomez Vidal, J. A.; Erdal, E. U.S. Patent 7,470,815 (Dec. 30, 2008). “Selective Neuronal Nitric Oxide Synthase Inhibitors”
  • Silverman, R. B.; Andruszkiewicz, R.; Yuen, P.-W. Japan Pat. 4,297,814 (April 24, 2009) “GABA and L-Glutamic Acid Analogs for Antiseizure Treatment.”
  • Silverman, R. B.; Liu, S.; Gu, W.; Adrian, T.; Soff, G. U.S. Patent 7,709,443 (May 4, 2010). “Cyclic Peptide Antitumor Agents.”
  • Silverman, R. B.; Ji, H.; Lawton, G. R. U.S. Patent 7,994,326 (August 9, 2011). Potent and Highly Selective Heteroaromatic Inhibitors of Neuronal Nitric Oxide Synthase.
  • Silverman, R. B.; Liu, S.; Gu, W.; Adrian, T. E.; Soff, G. A. U.S. Patent 8,058,244 B2 (Nov. 15, 2011). “Cyclic Peptide Antitumor Agents.”
  • Silverman, R. B.; Ji, H. U.S. Patent 8,158,658 B2 (April 17, 2012). Heteroaromatic selective inhibitors of neuronal nitric oxide synthase
  • Ilan, Y.; Zigmond, E.; Silverman, R. B.; Lu, H. U.S. Patent 8,211,865 B2 (July 3, 2012). Inhibition of ornithine aminotransferase for the treatment of proliferative disorders.
  • Silverman, R. B.; Xue, F. U.S. Patent 8,278,084 B2 (October 2, 2012). Aminopyridine diner compounds, compositions and related methods for neuronal nitric oxide synthase inhibition
  • Silverman, R. B.; Xue, F. U.S. Patent 8,299,100 B2 (October 30, 2012). Potent and selective neuronal nitric oxide synthase inhibitors with improved membrane permeability
  • Silverman, R. B.; Xue, F. U.S. Patent 8,389,731 B2 (March 5, 2013). Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase
  • Silverman, R. B.; Liu, S.; Gu, W.; Adrian, T. E.; Soff, G. A. U.S. Patent 8,492,345 B2 (July 23, 2013). Cyclic peptide antitumor agents
  • Silverman, R. B.; Ji, H.; Huang, H. U.S. Patent 8,557,552 B2 (October 15, 2013). Selective neuronal nitric oxide synthase inhibitors
  • Silverman, R. B.; Kraus, J. M. U.S. Patent 8,618,143 B1 (December 31, 2013). Selective neuronal nitric oxide synthase inhibitors with azole substituents
  • Meyskens, F. L., Jr.; Silverman, R. B.; Yang, S.; Ji, H.; Xue, F.; Poulos, T. P. U.S. Patent 8,642,282 B2 (February 4, 2014). Inhibitors of nitric oxide synthase for treatment of melanoma
  • Ilan, Y.; Zigmond, E.; Silverman, R. B.; Lu, H. U.S. Patent 8,686,041 B2 (April 1, 2014). Inhibition of ornithine aminotransferase for the treatment of proliferative disorders
  • Silverman, R. B.; Xue, F. U.S. Patent 8,697,879 B2 (April 15, 2014). Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors
  • Silverman, R. B.; Kudoh, T. U.S. Patent 8,710,032 B2 (April 29, 2014). Inhibitors of the mevalonate pathway of Streptococcus pneumonia
  • Kirsch D. R.; Benmohamed, R.; Arvanites, A. C.; Morimoto, R. I.; Zhang, W.; Silverman, R. B. U.S. Patent 8,722,939 B2 (May 13, 2014). Cyclohexane-1,3-diones for use in the treatment of amyotrophic lateral sclerosis
  • Silverman, R. B.; Huang, H.; Jing, Q. U.S. Patent 8,735,606 B2 (May 27, 2014). Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors
  • Silverman, R. B.; Xue, F. U.S. Patent 8,829,187 B1 (September 9, 2014). Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase
  • Silverman, R. B.; Xue, F. U.S. Patent 8,927,730 B2 (January 6, 2015). Intramolecular hydrogen-bonded nitric oxide synthase inhibitors
  • Silverman, R. B.; Xue, F.; Huang, H. U.S. Patent 8,932,842 B2 (January 13, 2015). Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition
  • Silverman, R. B.; Dewey, S. L.; Miller, S. U.S. Patent 8,969,413 B2 (March 3, 2015). Methods of using (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid
  • Silverman, R. B.; Meyskens, F. L.; Yang, S.; Ji, H.; Xue, F.; Poulos, T. L. U.S. Patent 9,090,589 B2 (July 28, 2015). Specific nNOS inhibitors for the therapy and prevention of human melanoma
  • Silverman, R. B.; Jing, Q. U.S. Patent 9,120,750 B2 (September 1, 2015). 2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors
  • Silverman, R. B.; Zhang, Y. U.S. Patent 9,145,424 B2 (September 29, 2015). Treatment of amyotrophic lateral sclerosis
  • Silverman, R. B.; Watanabe, M.; Kang, S. S.; Leyh, T. S. U.S. Patent 9,150,534 B2 (Oct. 6, 2015). Prodrugs of fluorinated mevalonates to inhibit the mevalonate pathway of Streptococcus pneumonia
  • Kirsch, D.; Benmohamed, R.; Arvanites, A. C.; Morimoto, R. I.; Zhang, W.; Silverman, R. B. U.S. Patent 9,162,968 B2 (Oct. 20, 2015). Cyclohexane-1,3-diones for use in the treatment of amyotrophic lateral sclerosis
  • Silverman, R. B.; Cinelli, M.; Pensa, A. V. U.S. Patent 9,212,144 B2 (Dec. 15, 2015). 2-Aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition
  • Xue, F.; Silverman, R. B. U.S. Patent 9,212,161 B2 (Dec. 15, 2015). Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors
  • Silverman, R. B.; Huang, H.; Jing, Q. U.S. Patent 9,242,957 B2 (Jan. 26, 2016). Thiophene-2-carboximidamide based selective neuronal nitric oxide synthase inhibitors
  • Silverman, R. B.; Wang, H.; Khanfar, M.; Kazantsev, A. G. U.S. Patent 9,371,277 B2 (June 21, 2016). Benzamide compounds and related methods of use
  • Silverman, R. B.; Jing, Q. U.S. Patent 9,416,106 B2 (Aug. 16, 2016). 2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors
  • Surmeier, D. J., Jr.; Silverman, R. B.; Kang, S.; Cooper, G. U.S. Patent 9,428,467 B2 (Aug. 30, 2016). Selective calcium channel antagonists
  • Kirsch, D. R.; Benmohamed, R.; Arvanites, A. C.; Morimoto, R. I.; Xia, G.; Silverman, R. B. Eur. Patent (Oct. 12, 2016). Pyrimidine-2,4,6-triones for use in the treatment of amyotrophic lateral sclerosis
  • Kirsch, D. R.; Benmohamed, R.; Arvanites, A. C.; Morimoto, R. I.; Xia, G.; Silverman, R. B. U.S. Patent 9,499,494 B2 (Nov. 22, 2016). Pyrimidine-2,4,6-triones for use in the treatment of amyotrophic lateral sclerosis
  • Silverman, R. B.; Wang, H.; Khanfar, M.; Kazantsev, A. G. U.S. Patent 9,533,947 B2 (Jan. 3, 2017). Benzamide compounds and related methods of use
  • Kirsch, D. R.; Benmohamed, R.; Arvanites, A. C.; Morimoto, R. I.; Zhang, W.; Silverman, R. B. U.S. Patent 9,593,069 B2 (Mar. 14, 2017). Cyclohexane-1,3-diones for use in the treatment of amyotrophic lateral sclerosis
  • Silverman, R. B.; Ilan, Y. U.S. Patent 9,603,820 B2 (Mar. 28, 2017). Ornithine aminotransferase inhibition with GABA analogues for treatment of hepatocellular carcinoma
  • Silverman, R. B.; Cinelli, M. A.; Pensa, A. V. U.S. Patent 9,663,468 B2 (May 30, 2017). 2-Aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition

  • Silverman, R. B.; Takaya, K.; Le, H. V.; Juncosa, J. I. U.S. Patent 9,670,141 B2 (June 6, 2017). (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as GABA aminotransferase inactivators for the treatment of epilepsy, addiction and hepatocellular carcinoma

  • Silverman, R. B.; Huang, H.; Jing, Q. U.S. Patent 9,682,950 B2 (June 20, 2017). Thiophene-2-carboximidamide based selective neuronal nitric oxide synthase inhibitors

  • Silverman, R. B.; Mukherjee, P.; Nguyen, H. M. U.S. Patent 9,701,661 B2 (July 11, 2017). 2-Imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase
  • Silverman, R. B.; Jing, Q. U.S. Patent 9,732,037 B2 (Aug. 15, 2017). 2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors
  • Silverman, R. B.; Xue, F. U.S. Patent 9,758,507 B2 (Sept. 12, 2017). Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors
  • Silverman, R. B.; Xue, F. U.S. Patent 9,765,055 B2 (Sept. 19, 2017). Intramolecular hudrogen-bonded nitric oxide synthase inhibitors
  • Silverman, R. B.; Cinelli, M. A.; Pensa, A. V. U.S. Patent 9,783,500 (Oct. 10, 2017). 2-Aminoquinoline-based compounds for potent and selective neuronal nitric oxides synthase inhibition
  •  Krainc, D.; Silverman, R. B.; Zheng, J. U.S. Patent 9,802,942 B2 (Oct. 31, 2017). Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity

  • Silverman, R. B.; Zhang, Y. U.S. Patent 9,809,556 B2 (Nov. 7, 2017). Treatment of amyotrophic lateral sclerosis

  • Silverman, R. B.; Hawker, D. D.; Le, H. V. U.S. Patent 9,856,231 B2 (Jan. 2, 2018). Tetrahydrothiophene-based GABA aminotransferase inactivators
  • Silverman, R. B.; Mukherjee, P.; Nguyen, H. M. U.S. Patent 9,878,996 B2 (Jan. 30, 2018). 2-Imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase
  • Silverman, R. B.; Wang, H.; Khanfar, M.; Kazantsev, A. G. U.S. Patent 9,890,117 B2 (Feb. 13, 2018). Benzamide compounds and related methods of use
  • Silverman, R. B.; Jing, Q.; Kang, S.; Wang, H.-Y. U.S. Patent 9,951,014 B2 (Apr. 24, 2018). Mammalian and bacterial nitric oxide synthase inhibitors
  • Silverman, R. B.; Takaya, K.; Le, H. V.; Juncosa, J. I. U.S. Patent 9,993,449 B2 (June 12, 2018). (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as GABA aminotransferase inactivators for the treatment of epilepsy, addiction and hepatocellular carcinoma
  • Krainc, D.; Silverman, R. B.; Zheng, J. U.S. Patent 10, 040,799 B2 (Aug. 7, 2018). Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity
  • Surmeier, D. J., Jr.; Silverman, R. B.; Kang, S. S.; Cooper, G. U.S. Patent 10,105,366 B2 (Oct. 23, 2018). Selective calcium channel antagaonists
  • Kirsch, D. R.; Benmohamed, R.;Arvanites, A. C.; Morimoto, R. I.; Chen, T.; Silverman, R. B. Canada Patent CA 2,744,016 (Dec. 11, 2018). Treatment of amyotrophic lateral sclerosis
  • Silverman, R. B.; Jing, Q. U.S. Patent 10,167,260 B2 (Jan. 1, 2019). 2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors
  • Kirsch, D. R.; Benmohamed, R.;Arvanites, A. C.; Morimoto, R. I.; Chen, T.; Silverman, R. B. U.S. Patent 10,167,263 B2 (Jan. 1, 2019). Treatment of amyotrophic lateral sclerosis
  • Krainc, D.; Silverman, R. B.; Zheng, J. U.S. Patent 10,167,270 B2 (Jan. 1, 2019). Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity
  • Silverman, R. B.; Le, H. V.; Hawker, D. D. U.S. Patent 10,189,807 B2 (Jan. 29, 2019). Tetrahydrothiophene-based GABA aminotransferase inactivators
  • Krainc, D.; Silverman, R. B.; Zheng, J. U.S. Patent 10,227,352 B2 (Mar. 12, 2019). Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity
  • Krainc, D.; Silverman, R. B.; Zheng, J. U.S. Patent 10,442,812 (Oct. 15, 2019) Substituted 4-methyl-pyrrolo[1,2-A]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity
  • Silverman, R. B.; Zhang, Y. U.S. Patent 10,526,289 B2 (Jan. 7, 2020). Substituted pyrazolone compounds for use in treatment of amyotrophic lateral sclerosis
  • Juncosa, J.; Le, H. V.; Silverman, R. B.; Takaya, K., Columbia Patent Certificado Numero 37025 (Apr. 17, 2020). Compuestos derivados del ácido (S)-3-amino-4-(difluorometilenil)ciclopent-1-eno-1-carboxílico como inhibidores de GABA aminotransferase
  • Silverman, R. B.; Le, H. V.; McLeod, R. L.; Hawker, D. D. U.S. Patent 10,632,088 B2 (Apr. 28, 2020). Inactivators of Toxoplasma gondii ornithine aminotransferase for treating toxoplasmosis and malaria
  • Silverman, R. B.; Wang, H.-Y.; Qin, Y.; Zou, F.; Kang, S.; Jing, Q. U.S. Patent 10,759,791 B2 (Sept. 1, 2020). Mammalian and bacterial nitric oxide synthase inhibitors
  • Ilan, Y.; Silverman, R. B. Israel Patent IL 252042 (September 1, 2020). Ornithine Aminotransferase Inhibition with GABA Analogues for Treatment of Hepatocellular Carcinom
  • Silverman, R. B.; Le, H. V.; Hawker, D. D. U.S. Patent 10,800,753 B2 (Oct. 13, 2020). Tetrahydrothiophene-based GABA aminotransferase inactivators and analogs thereof for treating neurological disorder
  • Silverman, R.B.; Ni, C.-L.; Juncosa, J. I. U.S. Patent 10,822,301 B2 (Nov. 3, 2020). 3-Carbon substituted 4-aminocyclopent-1-ene-1-carboxylic acid compound
  • Krainc, D.; Silverman, R. B.; Zheng, J. U.S. Patent 10,882,865 B2 (Jan. 5, 2021). Pyrrolopyrimidine compounds and uses thereof for modulating glucocerebrosidase activity
  • Silverman, R. B.; Juncosa, J.; Le, H. V.; Takaya, K. China Patent, ZL 2016800590699 (February 12, 2021). (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, a Highly Potent GABA Aminotransferase Inactivator for the Treatment of Epilepsy, Addiction and Hepatocellular Carcinoma
  • Silverman, R. B.; Juncosa, J.; Le, H. V.; Takaya, K. Japan Patent, JP 6841821 (February 22, 2021). (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as GABA Aminotransferase Inactivators for the Treatment of Epilepsy, Addiction and Hepatocellular Carcinoma
  • Krainc, D.; Silverman, R. B.; Zheng, J. U.S. Patent 10,934,270 B2 (Mar. 2, 2021). Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity
  • Silverman, R. B.; Juncosa, J.; Le, H. V.; Takaya, K. Israel Patent, IL 258516 (April 1, 2021). (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, a Highly Potent GABA Aminotransferase Inactivator for the Treatment of Epilepsy, Addiction and Hepatocellular Carcinoma
  • Ilan, Y.; Silverman, R. B. Japan Patent JP 6867949 (April 13, 2021). Ornithine Aminotransferase Inhibition with GABA Analogues for Treatment of Hepatocellular Carcinoma
  • Silverman, R. B.; Takaya, K.; Le, H. V.; Juncosa, J. I. Australia Patent AU 2016334396 (July 22, 2021). (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as GABA aminotransferase inactivators for the treatment of epilepsy, addiction and hepatocellular carcinoma
  • Silverman, R. B.; Takaya, K.; Le, H. V.; Juncosa, J. I. India Patent IN 372532 (July 23, 2021). (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as GABA aminotransferase inactivators for the treatment of epilepsy, addiction and hepatocellular carcinoma