Curriculum Vitae
Address:
Department of Chemistry
Northwestern University
2145 Sheridan Road
Evanston, IL 60208-3113
Telephone: (847)491-5653
Fax: (847)491-7713
Email: Agman@chem.northwestern.edu
Date of Birth:
May 12, 1946
Philadelphia, PA
Marital Status:
Married, 3 children
Positions Held:
- 9/19-present Patrick G. Ryan/Aon Professor, Department of Chemistry, Department of Molecular Biosciences, Evanston, IL; Department of Pharmacology, Feinberg School of Medicine, Chicago IL, Northwestern University
- 9/18-present Patrick G. Ryan/Aon Professor, Associate Chair, Department of Chemistry, Northwestern University
- 9/15-present Patrick G. Ryan/Aon Professor
- 9/04-8/15 John Evans Professor of Chemistry, Northwestern University
- 9/01-9/04 Charles Deering McCormick Professor of Teaching Excellence, Northwestern University
- 9/10-present Professor of Chemistry and Professor of Molecular Biosciences, Northwestern University
- 1/96-1/98 Arthur Andersen Professor of Chemistry and of Biochemistry, Molecular Biology, and Cell Biology; Northwestern University
- 9/86 – 9/10 Professor of Chemistry and Professor of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University
- 9/84 – 9/86 Associate Professor of Chemistry and Associate Professor of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University
- 9/82 – 9/84 Associate Professor of Chemistry, Northwestern University
- 9/76 – 9/82 Assistant Professor of Chemistry, Northwestern University
Education:
- 9/68- 1/69 Harvard University (Advisor: Professor David H. Dolphin, Department of Chemistry)
- 1/71 – 6/74 Ph.D. in organic chemistry. Thesis: Model Studies for Coenzyme B12-Dependent Enzyme-Catalyzed Rearrangements.
- 4/64 – 3/68 Pennsylvania State University B.S. in chemistry
Postdoctoral Experience:
- 7/74 – 9/76 Brandeis University (Advisor: Professor Robert H. Abeles, Graduate Department of Biochemistry) Specific Enzyme Inactivation
Military Service:
- 1/69 – 1/71 United States Army Physical Sciences Assistant, Walter Reed Army Institute of Research, Washington, D.C., Honorable discharge, 1/71
Other Research Experience
- 5/69 – 1/71 Walter Reed Army Institute of Research
Synthesis of potential anti-radiation agents - 4/68 – 9/68 Rohm and Haas Company
Synthesis of elastomeric fibers - 4/67 – 1/68 Pennsylvania State University
B.S. Thesis: Some Chemistry of Tungsten Carbony Carbene Complexes - 6/66 – 9/66 Atlantic-Richfield
Fuel cell research
Professional Memberships:
- American Chemical Society
- American Association for the Advancement of Science
- American Society for Biochemistry and Molecular Biology
- Royal Society of Chemistry (UK)
Research Interests:
- Medicinal and bioorganic chemistry: mechanism of drug action;
design of medicinal agents; specific enzyme inactivation;
enzyme mechanisms; enzyme models
Awards
Pennsylvania State University
- Magna Cum Laude
- National Chemistry Honor Society (Phi Lambda Upsilon)
- National Science Honor Society (Phi Kappa Phi)
- National Freshmen Scholastic Honor Society (Phi Eta Sigma)
- J. Paul Smith Memorial Scholarship, 1966-1968
- Alumni Fellow Award, 2008
United States Army
- U.S. Army Commendation Medal for meritorious service 1971
Harvard University
- NIH Predoctoral Training Grant 1971-1974
- Outstanding Teaching Fellow Fall, 1973 (excellence in teaching organic chemistry)
Brandeis University
- NIH Postdoctoral Fellowship 7/74 – 9/76 (declined an American Cancer Society Postdoctoral Fellowship)
Northwestern University
- Du Pont Young Faculty Fellow 1976
- Alfred P. Sloan Research Fellow 1981-1985
- NIH Research Career Development Awardee 1982-1987
- Fellow of the American Institute of Chemists 1985
- Fellow of the American Association for the Advancement of Science 1990
- Northwestern University Faculty Honor Roll (based on undergraduate students’ 1977-1982, evaluations of teaching) (top 3%) 1978-1979, 1986, 1997, 2008
- E. LeRoy Hall Award for Teaching Excellence 1999
- Northwestern University Alumni Teaching Award 2000
- Arthur C. Cope Senior Scholar Award of the ACS 2003
- Alumni Fellow Award, Pennsylvania State University 2008
- Perkin Medal, Society of Chemical Industry 2009
- Medicinal Chemistry Hall of Fame of the ACS 2009
- Alumni Hall of Fame, Central High School of Philadelphia 2011
- E. B. Hershberg Award for Important Discoveries in Medicinally Active Substances of the ACS 2011
- Fellow of the American Chemical Society 2011
- Sato Memorial International Award of the Pharmaceutical Society of Japan 2012
- Roland T. Lakey Award from Wayne State University 2013
- Bristol-Myers Squibb-Edward E. Smissman Award of the American Chemical Society 2013
- Centenary Prize of the Royal Society of Chemistry 2013
- Fellow of the Royal Society of Chemistry (UK) 2013
- Medicinal Chemistry Prize of the Israel Chemical Society 2014
- Northwestern University Trustee Medal for Faculty Innovation and Entrepreneurship 2014
- iCON Innovator Award of the iBIO Institute 2014
- Fellow, American Academy of Arts & Science 2014
- Fellow, National Academy of Inventors 2014
- Creative Invention Award of the American Chemical Society (ACS) 2017
- Tetrahedron Prize for Creativity in Organic Chemistry 2021
- Member, National Academy of Sciences 2023
- Abeles and Jencks Award for the Chemistry of Biological Processes of the Division of Biological Sciences, ACS 2024
Honors and Other Professional Activities
- Pharmaceutical Inventions
- Inventor of LyricaTM (pregabalin), marketed worldwide by Pfizer for the treatment of epilepsy, neuropathic pain, fibromyalgia, and (in Europe) for generalized anxiety disorder. 2005-present
- Inventor of CPP-115, successful completion of Phase 1 clinical trial; currently used as compassionate use drug for children with infantile spasms 2016-2019
- Inventor of OV329, licensed to OVID Therapeutics 2016-present
- Companies Founded – AKAVA Therapeutics, LLC: focus on inhibition of enzymes, of protein aggregation and of cancer 2019-present
- Editorial Boards
- ACS Medicinal Chemistry Letters 2009-present
- Current Enzyme Inhibition 2004-present
- Bioorganic & Medicinal Chemistry 2003-present
- Bioorganic & Medicinal Chemistry Letters 2003-present
- Journal of Medicinal Chemistry 1995-2000
- Archiv Der Pharmazie Pharmaceutical and Medicinal Chemistry 1995-2014
- Archives of Biochemistry and Biophysics 1993-2003
- Enzyme Inhibition and Medicinal Chemistry 1988-2012
- InScight 1999-2010
- Section Editor for The Practice of Medicinal Chemistry, 3rd edition, Wermuth, C. G., editor 2007-2008
- Guest Editor for a Symposium-in-Print in Bioorganic and Medicinal Chemistry 1996
- Editorial Board of Reviewers for the textbook Biochemistry, Abeles, R. H.; Frey, P. A.; Jencks, W. P.; Jones and Bartlett: Boston 1992
- Scientific Advisory Boards
- Influx, Inc. 1998-2003
- Protez Pharmaceuticals, Inc. 2004-2010
- SynChem, Inc. 2004-present
- University of Illinois, Chicago, NIH Anthrax Project 2006
- University of Illinois, Chicago, NIH SARS Project 2007
- Cambria Pharmaceuticals LLC 2007-2012
- Catalyst Pharmaceuticals 2010-present
- Brandeis University Science Advisory Council 2011-2014
- Advisory Committee to the Board of the Malta Conferences Foundation 2011-present
- Science Research Center, Ewha Womans University, Seoul, Korea 2015-present
- Global AI Drug Discovery Center Advisory Board, Ewha Womans University, Seoul, Korea 2020-present
- Chicago Biomedical Consortium Accelerator Review Board 2020-present
- Radyus Research Inc. (Atlanta, GA) 2020-present
- International Advisory Committees
- 10th International Amine Oxidase Workshop 8/2002
(Istanbul, Turkey) - XVIIIth International Symposium on Medicinal Chemistry (Copenhagen, Denmark) 9/2004
- Malta Conferences 2011-present
- 10th International Amine Oxidase Workshop 8/2002
- National Offices Held
- Elected Office: Program Chair, Division of Biological Chemistry, ACS 2001
- Member, Long-Range Planning Committee for the Division of Medicinal Chemistry, ACS 1999-2002
- Elected Office: Treasurer, Division of Biological Chemistry, American Chemical Society 1993-1996
- Elected Office: Nominating Committee, Division of Biological Chemistry of the American Chemical Society 1990
- Elected Office: Program Chair, Division of Biological Chemistry, ACS 2001
- Member, Canvassing Committee for the American Chemical Society Alfred Burger Award in Medicinal Chemistry 1982-1987
- Chairman 1986-1987
- Member, American Chemical Society Organic Chemistry Examination Committee 1986
- NIH Advisory Panels
- Permanent member, Bioorganic and Natural Products Chemistry Study Section 1987-1991
- NIH Reviewer for Therapeutics for Rare and Neglected Diseases Study Section Dec., 2011, 2012
- NIH Ad hoc Reviewer for Moleular Structure and Function of Enzymes Study Section, June 2007
- NIH Ad hoc Reviewer for Center for Scientific Review Special Emphasis Panel November 2005
- NIH Ad hoc Reviewer for Macromolecular Structure and Function Study Section March 2005
- National INstitutes of General Medical Sciences Advisory Council September 2002
- NIH Ad hoc Reviewer for Bioorganic & Medicinal Chemistry Study Section Oct., 2001
- NIH Ad hoc Reviewer for Chemistry and Related Sciences Study Section Nov., 1996
- NIH Ad hoc Reviewer for Medicinal Chemistry A Study Section (AREA proposals) Nov., 1993
- NIH Special Reviewer for Bio-Organic and Natural Products Chemistry Study Section Feb., 1987
- NIH Special Study Sections 12/83; 7/85
- NIH Program Project Site Visits and Special Pharmacological Sciences Review Committees:
- University of Washington Feb., 1983
- University of Kansas June, 1981
- Conference Organizer/Chair
- Organizer, 25th Enzyme Mechanisms Conference 2017
- Organizer, 37th ACS Great Lakes Region Meeting 2006
- XVIII International Symposium on Medicinal Chemistry (Copenhagen, Denmark) 2004
- Organizer of the entire program for the Division of Biological Chemistry of the Am. Chem. Soc. National Meeting 2001
- Organizer and Chair, Symposium on Dual-Acting Drugs, ACS Nat’l Meeting (DC) 2000
- Session Chair, 5th Chemical Congress of North America Symposium on NO Synthase Inhibitors 1997
- Program Committee, National Medicinal Chemistry Symposium 1996
- Co-Chair Gordon Research Conference on Enzymes, Coenzymes, and Metabolic Pathways 1994
- Co-Vice Chair, Gordon Research Conference on Enzymes, Coenzymes, and Metabolic Pathways 1993
- Organizer and Chairman of the 2nd, 14th and 26th Annual Midwest Enzyme Chemistry Conference, Chicago 1982, 1994, 2006, 2010
- Organizer and Chairman of the Northwestern UniversityDepartment of Chemistry Byron Riegel Lecture Series (Mechanism of Action and Design of Drugs) 1980
- Expert Analyst for CHEMTRACTS 1988-1994
- Special Lectureships
- Plenary Lecturer, 4th Society of Chemical Industry-Royal Society of Chemistry, Medicinal Chemistry Symposium (Cambridge, England) Sept., 1987
- Plenary Lecturer, 14th Scientific Sessions of the Rhone-Poulenc Society (Lyon, France) Nov., 1991
- Pew Lecturer, Wheaton College (Wheaton, IL) Apr., 1992
- Plenary Lecturer, 20th Anniversary Marion Merrell Dow Research Institute (Strasbourg, France) May, 1993
- Peters Lecturer, Virginia Polytechnic Institute and State University (Blacksburg, VA) Oct., 1993
- Burkett Lecturer, DePauw University (Greencastle, IN) Apr., 1994
- Teaching faculty at the Residential School on Medicinal Chemistry, Drew University (Madison, NJ) 1995-present
- Plenary Lecturer, VII Meeting on Heterocyclic Structures in Medicinal Chemistry (Mondello, Sicily) May, 1996
- Plenary Lecturer, University of Pennsylvania enzyme Symposium III (Philadelphia, PA) 1997
- Plenary Lecturer, 40th Annual MIKI Meeting (Chicago, IL) 2002
- Plenary Lecturer, Norwegian Organic Chemistry Winter Meeting (Roros, Norway) 2004
- Frontier Science Lecturer, Wayne State University, Department of Chemistry (Detroit, MI) 2004
- Plenary Lecturer, Science at the Interface of Chemistry and Biology, University of Notre Dame, Department of Chemistry and Biochemistry (South Bend, IN) 2004
- Plenary Lecturer, International Conference on Chemistry Biology Interface: Synergistic New Frontiers (Dr. B.R. Ambedkar Center for Biomedical Research, New Delhi, India) 2004
- Plenary Lecturer, IVth National Meeting on Medicinal Chemistry, (Caracas, Venezuela) 2007
- Kilpatrick Lecturer, Illinois Institute of Technology (Chicago, IL) 2008
- Plenary Lecturer, Royal Australian Chemical Institute, Division of Biomolecular Chemistry (Couran Cove, QLD, Australia) 2008
- Ira Kukin Chemistry Lecturer, Yeshiva University (New York, NY) 2009
- Plenary Lecturer, Canadian Society for Chemistry (Toronto, Ontario, Canada) 2010
- Tyler Lecturer, Purdue University (West Lafayette, IN) 2010
- Bernard Belleau Lecturer, McGill University (Montreal, Quebec, Canada) 2011
- Len Owen Lecturer, Imperial College (London, UK) 2013
- Jack Fox Memorial Lecturer, Memorial Sloan-Kettering Cancer Center (New York, NY) 2014
- Kenneth L. Rinehart, Jr. Lecturer in Chemical Biology, University of Illinois at Urbana-Champaign 2014
- Nakamoto Lecturer, Marquette University 2015
- Hovey Lecturer, Wabash College 2015
- Dean’s Distinguished Lecturer, Temple University 2016
- Probst Lecturer, Southern Illinois University, Edwardsville 2016
- Wawzonek Lecturer, University of Iowa 2016
- Medicinal Chemistry Distinguished Lecturer, University of Minnesota 2016
- Lilly-Brown Lecturer, Purdue University 2016
- John C. Wriston Memorial Lecture, University of Delaware 2017
- Doyle Smith/Larry Winter Lecturer, Virginia Commonwealth University 2018
- Keynote Lecturer, EFMC International Symposium on Medicinal Chemistry (Ljubljuana, Slovenia) 2018
- Plenary Lecturer, Mid-Atlantic Pharmacology Society Meeting (Philadelphia, PA) 2019
- Keynote Lecturer, Medical Innovation Summit (Cleveland, OH) 2019
- Inaugural Gilead Sciences Lecturer, Scripps Research Institute 2019
- Frontier Science Lecturer Wayne State University (Detroit, MI) 2019
- C.S. Hamilton Award Lecturer, University of Nebraska (Lincoln, NE) 2020
- Houk-Jung Colloquium Lecturer, UCLA (Los Angeles, CA) 2021
- Welcher Lecturer, IUPUI (Indianapolis, IN) 2021
- Consultantships
- Procter and Gamble 1984
- Abbott Laboratories 1987
- Searle/Monsanto 1988-1990
- Leydig, Voit & Mayer Law Offices 1992-present
- DowElanco 1993-1995
- Searle & Co. 1995
- Rohm & Haas 1995
- Affymax 1995
- Kinetek Pharmaceuticals 1999
- Guilford Pharmaceuticals (Baltimore MD) 2001
- ActivX Biosciences (La Jolla, CA) 2001
- Cytoclonal Pharmaceutics (now eXegenics) (Dallas, TX) 2001
- Hawaii Biotech, Inc. (Aiea, HI) 2003-2006
- Dyad Therapeutics, INc. (Berkeley, CA) 2020-present
- Short Courses Given
- “The Organic Chemistry of Enzyme-Catalyzed Reactions”
- E.I. Du Pont de Nemours 9/91
- Dow Chemical Company 9/91
- American Chemical Society National Meeting (San Francisco) 4/92
- Indianapolis Section of the American Chemical Society 12/92
- American Chemical Society National Meeting (Chicago) 8/93
- Procter & Gamble Pharmaceuticals 11/94
- BioChem Pharma, Inc. 4/99
- “The Organic Chemistry of Drug Design and Drug Action”
- American Chemical Society National Meeting (Anaheim) 4/95
- American Chemical Society National Meeting (Chicago) 8/95
- Western Regional American Chemical Society Meeting (San Diego) 10/95
- American Chemical Society (Somerset, NJ) 11/95
- American Chemical Society (New Orleans, LA) 3/96
- American Chemical Society (Orlando, FL) 8/96
- American Chemical Society (Boston, MA) 12/96
- American Chemical Society (San Francisco, CA) 4/97
- American Chemical Society (Philadelphia, PA) 4/97
- Bayer Pharmaceuticals (West Haven, CT) 5/97
- American Chemical Society (Las Vegas, NV) 9/97
- American Chemical Society (Dallas, TX) 4/98
- Pharmaceutical Ingredients Society (Philadelphia, PA) 5/98
- St. Louis Section of ACS 5/98
- American Chemical Society (Boston, MA) 8/98
- PITTCON (Orlando, FL) 3/99
- American Chemical Society (Anaheim, CA) 3/99
- Eli Lilly and Co. (Indianapolis, IN) 6/99
- Drug Discovery Technology ’99 (Boston, MA) 8/99
- American Chemical Society (New Orleans, LA) 8/99
- WorldPharm ’99 (Philadelphia, PA) 10/99
- San Francisco (c/o ACS) 12/99
- Hoffmann-La Roche (Nutley, NJ) 12/99
- Pittcon (New Orleans, LA) 3/00
- Bayer (Kyoto, Japan) 3/00
- AstraZeneca (St. Laurent, Quebec, Canada) 6/00
- Sphinx Pharmaceuticals (Research Triangle Park, NC) 6/00
- Drug Discovery Technology 2000 (Boston, MA) 8/00
- American Chemical Society (Washington, DC) 8/00
- Bristol-Myers Squibb (Wallingford, CT) 9/00
- American Chemical Society (San Diego, CA) 4/01
- Bristol-Myers Squibb (Princeton, NJ) 7/01
- Drug Discovery Technology 2000 (Boston, MA) 8/01
- American Chemical Society (Chicago, IL) 8/01
- American Chemical Society (San Francisco, CA) 12/01
- New York Police Department (Jamaica, NY) 3/02
- American Chemical Society (Orlando, FL) 4/02
- American Chemical Society (Boston, MA) 8/02
- American Chemical Society (Boston, MA) 11/02
- American Chemical Society (San Francisco, CA) 12/02
- PPD Discovery (Morrisville, NC) 12/02
- American Chemical Society (New Orleans, LA) 3/03
- Drug Discovery Technology 2003 (Boston, MA) 8/03
- American Chemical Society (New York, NY) 9/03
- Bristol-Myers Squibb (Wallingford, CT) 6/03
- American Chemical Society (San Francisco, CA) 12/03
- American Chemical Society (Anaheim, CA) 3/04
- Gilead Pharmaceuticals (Mountain View, CA) 4/04
- Pfizer Pharmaceuticals (San Diego, CA) 4/04
- Procter & Gamble (Cincinnati, OH) 5/04
- Bristol-Myers Squibb (Princeton, NJ) 6/04
- American Chemical Society (Philadelphia, PA) 8/04
- American Chemical Society (San Diego, CA) 3/05
- American Chemical Society (Washington, DC) 8/05
- Encysive Pharmaceuticals (Houston, TX) 11/05
- American Chemical Society (San Francisco, A) 9/06
- IVth National Meeting on Medicinal Chemistry (Caracas, Venezuela) 6/07
- “The Organic Chemistry of Enzyme-Catalyzed Reactions”
- Inclusion in International Biographical Texts
- Who’s Who in Frontiers of Science and Technology 1984, 1985
- International Who’s Who of Contemporary Achievement 1985
- Who’s Who in the Midwest 1986-1988, 1991
- Personalities of America 1986
- Who’s Who in Society 1986, 1988
- Men of Achievement 1986
- Who’s Who of Emerging Leaders in America 1987
- Who’s Who in America 1988-2010
- Who’s Who in American Education 1994-2008
- Who’s Who in Science and Engineering 1996-2008
- Who’s Who Among American’s Teachers 2000